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Two ways to take Semaglutide: Oral Tablets vs. Injections

What’s hotter than summer? Semaglutide. The rapid weight loss trend has swiftly grabbed headlines with Ozempic credited by billionaire Elon Musk and Real Housewives star Dolores Catania for their sleek physiques. And now that the Hollywood hype has hit mainstream, it seems everyone who has struggled to lose weight is curious—and with good reason. We break down just how semaglutide works, the two ways to take it, and our new proprietary semaglutide service—Slim Shot. 

How Does Semaglutide Work for Weight Loss?

To understand how semaglutide works for weight loss, let’s start with Ozempic’s original intent—to treat adults with Type 2 diabetes. Approved in 2017 by the U.S. Food and Drug Administration (FDA), Ozempic belongs to a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists.¹

One role of GLP-1 is to prompt the body to make more insulin and reduce blood sugar while sending messages to the brain that you’re not hungry. As hormone levels rise, the molecules go to your brain, telling it you’re full. They also slow digestion by increasing the time it takes for food to leave the body. In short, semaglutide works as  an appetite suppressant.

Taking Semaglutide: Oral Tablets vs. Injections

There are two effective ways to take semaglutide—oral tablets or injections. Wegovy and Ozempic are injectable versions, while Rybelsus is an oral tablet. 

Injectable semaglutide is typically administered once a week and should be injected into the upper arm, thigh, or stomach. It’s important to note that people injecting semaglutide should rotate the injection site after each shot—injecting in the same spot repeatedly can cause scar tissue to develop and the body may not absorb the medication effectively.²

Oral semaglutide is typically taken daily, in the morning, on an empty stomach. It is recommended to not eat for 30 minutes after. Injectable semaglutide, on the other hand, bypasses the digestive tract and can be taken with or without food.

Aside from dosing and administration, another notable difference between oral and injectable formulations of semaglutide is potency. While both formulations have been shown effective at reducing weight, injectable forms come in stronger formulations and are often started at a lower dose and gradually increased, while the oral form starts at 3 mg and can go up to 14 mg.³

Comparing Oral and Injectable Semaglutide

As found by Cover Health, both oral tablets and injectables have shown similar efficacy in clinical trials. However, a meta-analysis of studies indicates that patient tolerability and preference often lean towards the injectable form due to its less frequent dosing schedule.4 In addition to convenience, there is no delay in absorption making injectables extremely effective. Greenwich Medical Spa Clinical Director, Amanda Pucci, explains, “Injecting semaglutide straight into the subcutaneous tissue means the entire dose is accurately absorbed and works right away.” Pucci adds, “Whereas with oral tablets, your body has to digest the pill and can be affected by numerous factors like gut absorption, metabolism, and food intake.”

New GMS Semaglutide: Slim Shot 

If you, like many, are curious about semaglutide but not sure where to start, book a consultation with us at Greenwich Medical Spa. We are pleased to offer an incredible weight loss program, Slim Shot. Our proprietary combination of injectable semaglutide and vitamin B12 will decrease hunger, curb cravings, and reduce fat storage, as well as encourage a strong metabolism and boosted energy—all conveniently performed in the comfort of your own home. And, of course, with an experienced GMS clinician guiding you every step of the way. 


¹FDA. Medications Containing Semaglutide Marketed for Type 2 Diabetes or Weight Loss. January 2024. Source

²Catherine Crider. Taking Semaglutide: Oral Tablets vs. Injections. Healthline. July 2023. Source

³ ⁴Semaglutide Oral Vs Semaglutide Injection – Which to Take? Cover Health. January 2024. Source