Letybo, a new botulinum toxin, has just hit the U.S. market after gaining FDA approval for the treatment of moderate to severe glabellar lines (aka frown lines). With over a decade of clinical use globally and a strong safety profile, this blog will educate readers on what makes Letybo unique, how it compares to other neurotoxins, and who might benefit most from trying this next-generation wrinkle relaxer.
What is Letybo?
A neuromodulator that has been popular overseas for years, Letybo has finally arrived in the United States. Last year, it received FDA approval for treating glabellar lines, commonly known as the “11s,” which are the vertical lines between the eyebrows. Developed by Hugel, a South Korean biopharmaceutical company, Letybo is beginning to appear in more dermatology clinics, positioning itself as a potential rival to established players like Botox and Xeomin.
How Does Letybo Work?
Similar to Botox, Letybo blocks nerve signals to relax muscles, thus smoothing wrinkles caused by facial expressions. By inhibiting the release of acetylcholine, Letybo leads to reduced muscle activity and smoothing of glabellar lines.
Onset and Duration: Effects typically begin within 2-3 days post-injection, with maximum results observed between 7-14 days.
What Makes Letybo Different?
Letybo is a botulinum toxin type A product that includes accessory proteins in its formulation. According to the Australian Public Assessment Report, Letybo consists of a multimeric complex comprising a 150 kDa neurotoxin and associated non-toxic proteins, including hemagglutinins and non-haemagglutinating proteins. These accessory proteins are noncovalently associated with the neurotoxin and may contribute to the stability and activity of the product.
Letybo stands out due to its:
- High purity formulation
- Precise diffusion (Letybo is known for being more affordable than Botox)
- Potential for natural-looking results
- Smooth injection experience and fast onset
- Longer-lasting results, 3–4 months on average
Who is Letybo Ideal for?
Ideal Candidates: Letybo is suitable for individuals seeking a non-surgical solution for wrinkle reduction, including first-time neurotoxin users and those looking for a more cost-effective option.
Treatment Experience: Patients can expect a smooth, comfortable injection experience with predictable onset times, typically within 7-10 days.
Letybo vs. Botox, Dysport, Xeomin, Daxxify
Letybo, Botox, Dysport, Xeomin, and Daxxify are all neurotoxins used to relax muscles and reduce the appearance of wrinkles, but they differ in formulation and how they’re used.
Letybo (letibotulinumtoxinA): A newer, South Korean neurotoxin, Letybo is known for its high purity and consistent diffusion, offering similar results to Botox with a natural finish. It’s gaining popularity for its affordability and ability to provide smooth results.
Botox (onabotulinumtoxinA): The original and most widely used neurotoxin, Botox has a long history of use and is FDA-approved for various cosmetic and therapeutic purposes. Contains accessory proteins similar to those found in Letybo, forming a complex with the core neurotoxin.
Dysport (abobotulinumtoxinA): Dysport is known for its faster onset (results appearing in 2-3 days) and more diffusion than Botox, making it suitable for larger areas like the forehead. Also includes accessory proteins in its formulation, contributing to its diffusion characteristics.
Xeomin (incobotulinumtoxinA): Distinctly formulated without accessory proteins, often referred to as a “naked” neurotoxin. This absence may reduce the risk of antibody formation in some patients.
What to Expect During a Letybo Treatment
During a Letybo treatment, you can expect a swift, minimally invasive procedure that involves targeted injections into specific facial muscles. A consultation will take place to discuss your aesthetic goals and assess your facial structure, ensuring the best approach for your needs. The actual injection process is quick, usually lasting between 10 to 20 minutes, and most patients report only mild discomfort, often likened to a slight pinch. After the treatment, you can typically return to your daily activities right away, with full results becoming noticeable within 3 to 5 days and optimal effects appearing after about two weeks.
Post-treatment care may include avoiding pressure on the injection sites and remaining upright for a few hours, while regular follow-up sessions every 3 to 4 months are generally recommended to sustain your results.
Here’s a more detailed breakdown:
1. Consultation: Your provider will discuss your desired outcomes, assess your facial anatomy, and determine the appropriate injection sites.
2. Injection Process: Small amounts of Letybo are injected into the targeted muscles using a fine needle. The process is quick, typically taking 10-20 minutes.
3. Minimal Discomfort: Most patients report only mild discomfort, often described as a slight pinch.
4. No Downtime: You can usually resume your normal activities immediately after the procedure.
5. Results: Full results typically appear within 3-5 days, with optimal outcomes visible after about two weeks.
6. Aftercare: You may be advised to avoid rubbing the injection sites and to remain upright for several hours.
7. Follow-up: Regular follow-up treatments every 3-4 months are often recommended to maintain results.
Is Letybo Available at Greenwich Medical Spa?
Yes! Letybo is now available at Greenwich Medical Spa. Ready to try the newest wrinkle relaxer? Book your Letybo consultation today and see if it’s the right fit for your skin goals.
